منابع مشابه
Clonal dynamics of progressive neoplastic transformation.
In a recent study, we found that newly isolated clones of NIH 3T3 mouse cells undergo neoplastic transformation more readily than uncloned cultures from which they were derived. After eleven low-density passages (LDPs), most of the 29 clones produced lightly stained early-stage transformed foci when grown to confluence in a primary assay for transformation, and one of them consistently produced...
متن کاملNeoplastic transformation in longstanding fistula-in-ano.
A case in which an infiltrating mucinous carcinoma developed within a suprasphincteric fistula-in-ano is presented. The diagnosis was suspected on biopsy and confirmed by repeat biopsy. The clinical and histological features of this case establish with certainty that the carcinoma arose within the fistula and was not a secondary manifestation of the tumour. It is suggested that this rare compli...
متن کاملNeoplastic transformation induced by carbon ions.
PURPOSE The objective of this experiment was to compare the oncogenic potential of carbon ion beams and conventional photon beams for use in radiotherapy. METHODS AND MATERIALS The HeLa X human skin fibroblast cell line CGL1 was irradiated with carbon ions of three different energies (270, 100, and 11.4 MeV/u). Inactivation and transformation data were compared with those for 15 MeV photons. ...
متن کاملPleiotropic Role of HSF1 in Neoplastic Transformation
HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a probable reason for its high activity found in a ...
متن کاملDirect reprogramming en route to neoplastic transformation
Over the past years considerable effort has been directed toward identification of genes involved in cancer. We know now that mutations in more than 1% of human genes (out of ~20,000–25,000 genes in human genome) could play a role in cancer. Major advances have been made in understanding the processes involved in cancer progression. Much of this knowledge has come from the study of three relate...
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ژورنال
عنوان ژورنال: Nature
سال: 1977
ISSN: 0028-0836,1476-4687
DOI: 10.1038/268106a0